Local factors contribute to degeneration of cartilage and bone in a specific knee compartment (e.g. Systemic factors cause an osteoarthritic process in the entire knee joint characterized by associations among features across the entire joint. low-grade joint inflammation is a possible systemic factor. Systemic factors contribute to degeneration of cartilage and bone in all three knee compartments, e.g.
īoth systemic and local factors are involved in the aetiology of OA. Radiographic features are found in each of the three knee compartments: the medial tibiofemoral (MTF), lateral tibiofemoral (LTF) and patellofemoral (PF) compartments. All four features are supposed to be important in studying the onset and progression of the disease, although joint space narrowing and osteophyte formation are the most studied features. Radiographic hallmarks of knee OA include joint space narrowing, osteophyte formation, sclerosis and cysts. Knee osteoarthritis, radiographic features, compartment, inflammation Introduction Longitudinal studies are needed to explore the possibility of the development from a compartmental disease to a multicompartmental disease and the impact of contributing factors on the development. These findings suggest a multicompartmental disease process in the knee, characterized by associations among features across the entire joint, as well as compartmental disease processes in each knee compartment, characterized by associations among features within specific compartments. The bifactor model also showed three compartmental factors-one for each compartment: joint space narrowing, sclerosis and to a lesser extent osteophyte formation were associated with these compartmental factors.Ĭonclusion. A bifactor model showed a general multicompartmental factor: 10 of 12 radiographic features across the entire joint were associated with the general factor. Factor analysis was used to examine associations between the four radiographic features across and within compartments. Radiographic features were scored according to standardized scoring methods. In 298 patients diagnosed with knee OA, radiographic features were examined in three knee joint compartments. Data from the Amsterdam OA Cohort were used.
The aim of this study was to determine the associations between four radiographic features (joint space narrowing, osteophyte formation, sclerosis and cysts) across and within the three knee compartments (medial tibiofemoral, lateral tibiofemoral and patellofemoral compartment) in knee OA. Knee OA has been conceptualized as a multicompartmental disease, as a compartmental disease or as a combination of these two disease processes.
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